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Assay artifacts

Pharmacology data analysis for quantifying drug potency (Kd, EC50, Ki etc) was developed a century ago.

This analysis assumes the target density is low and the assay is at equilibrium.

These assumptions are often violated by new technology, e.g. in DEL and mass spec selections. We made a video and published a paper explaining the risks and how to mitigate them.

We also developed easy-to-use simulators to explore target density and equilibration artifacts in data analysis - see here.

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