Binding kinetics with PK  simulation

Currently the value of binding kinetics to drug discovery is a topic of debate. Specifically, how do binding kinetics affect occupancy when the ligand concentration is changing over time?

 

We have developed an Excel-based simulator to enable you to explore this yourselves, without the need to learn how to use sophisticated software. Check out the basic model below and contact sam.hoare@pharmechanics.com for more information.