About Pharmechanics

Pharmechanics was founded by Dr Sam Hoare in 2017, with the goal of helping pharmacologists analyze their data to accelerate drug discovery and basic research on drug targets.

Solving data analysis problems leads to innovation. An artifact clouds interpretation of results: Understanding that artifact reveals your compound is better than you think it is. An equation doesn't exist for measuring binding kinetics in your experiment: Deriving that equation opens up a whole new dimension of drug activity to explore.  It takes too long to perform the data analysis: Streamlining the analysis frees up your time to think and dwell on the results.

We can broaden the horizon of your pharmacology research and drug discovery projects.


Before founding Pharmechanics, Sam was with the Discovery Research group at Neurocrine Biosciences, where he was Lead Pharmacologist on multiple GPCR and transporter drug targets. He is particularly known for applying receptor kinetics to CRF1 receptor antagonist development, and for deciphering the mechanism of ligand interaction with Class B GPCRs. Sam received his PhD in biochemistry from the University of Kent in 1996 and then conducted postdoctoral research at the National Institute of Mental Health.